Trifluoroacetic acid → 2-Methyl-5-piperazin-1-yl-quinoline

HRID 15769

Reaktionsgleichung

Reaktionsgleichung von HRID 15769
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[N:3]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[N:3]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 49851900Tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylate

Produkt 1

HCID 498519012-Methyl-5-piperazin-1-yl-quinolineAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate (D2) (1.1 g) in a 25% solution of trifluoroacetic acid in dichloromethane (10 mL) was stirred at r.t. under an inert atmosphere for 3 hours. The reaction mixture was concentrated under reduced pressure and desalted by means of a 20 g SCX cartridge affording the title compound in 96% yield (0.74 g).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-314d2ca9bbee4079b72a99444a2f8f77
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732600B2

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