Hydrogen Bromide → 3-(Bromomethyl)-1-ethylpyrrolidine
Reaktionsgleichung
[CH2:1]([N:3]1[CH2:7][CH2:6][CH:5]([CH2:8]O)[CH2:4]1)[CH3:2].[BrH:10].C(=O)([O-])[O-].[Na+].[Na+]>>[Br:10][CH2:8][CH:5]1[CH2:6][CH2:7][N:3]([CH2:1][CH3:2])[CH2:4]1Komponenten
4
Versuchsvorschrift
A mixture of 5.0 g. (0.0388 mol.) of N-ethyl-3-hydroxymethylpyrrolidine and 50 ml. of 48% hydrogen bromide was refluxed for 17 hours. The reaction mixture was cooled, made basic by addition of solid sodium carbonate and extracted twice with methylene chloride. The combined extracts were dried (MgSO4) and evaporated to dryness to give 3-bromomethyl-N-ethylpyrrolidine.
Aufarbeitung
- additionA mixture of 5.0 g
- temperatureThe reaction mixture was cooled
- extractionextracted twice with methylene chloride
- dry with materialThe combined extracts were dried (MgSO4)
- customevaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-46401e28484943168e6253f41315513d
- Quelldatensatz
- uspto-grants-1976_09
- Patentnummer
- US03983245
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