1,3-Diethyl 2-oxopropanedioate → Ethyl 6,7-dichloro-3-hydroxyquinoxaline-2-carboxylate

HRID 1577806

Reaktionsgleichung

Reaktionsgleichung von HRID 1577806
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.O=[C:12]([C:18](OCC)=[O:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[N:9]=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:18](=[O:19])[NH:10]2

Komponenten

4

Edukt 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 792974,5-Dichloro-1,2-phenylenediamine

Produkt 1

HCID 6320212Ethyl 6,7-dichloro-3-hydroxyquinoxaline-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 17.7 g. of 4,5-dichloro-o-phenylenediamine in 200 ml. of anhydrous ethanol was prepared. A 17.4 g. batch of diethyl 2-ketomalonate were added to this solution and the mixture was heated to refluxing temperature for about 17 hours. The volatile constituents were removed by evaporation in vacuo. Recrystallization of the residue from ethanol yielded 20 g. of ethyl 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxaline carboxylate formed in the above reaction, melting in the range 226°-227° C.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto refluxing temperature for about 17 hours
  3. customThe volatile constituents were removed by evaporation in vacuo
  4. customRecrystallization of the residue from ethanol
  5. customyielded 20 g

Quellen und Nachweise

ORD-Eintrag
ord-a2b01a3b860942888662a28af9a29fcf
Quelldatensatz
uspto-grants-1981_09
Patentnummer
US04289773

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