2-Methyl-5-piperazin-1-yl-quinoline → 5-{4-[2-(3-Bromophenyl)ethyl]-1-piperazinyl}-2-methylquinoline

HRID 15779

Reaktionsgleichung

Reaktionsgleichung von HRID 15779
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([N+]([O-])=O)[CH:21]=3)[CH2:14][CH2:13]2)[N:3]=1.CC1C=CC2C(=CC=CC=2N2CCNCC2)N=1.CS(OCCC1C=CC=C([Br:59])C=1)(=O)=O>>[Br:59][C:22]1[CH:21]=[C:20]([CH2:19][CH2:18][N:15]2[CH2:14][CH2:13][N:12]([C:8]3[CH:7]=[CH:6][CH:5]=[C:4]4[C:9]=3[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]4)[CH2:17][CH2:16]2)[CH:25]=[CH:24][CH:23]=1

Komponenten

4

Edukt 3

HCID 498519012-Methyl-5-piperazin-1-yl-quinolineHCID 498519022-Methyl-5-(4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinolineHCID 57444273Benzeneethanol, 3-bromo-, 1-methanesulfonate

Produkt 1

HCID 574782845-{4-[2-(3-Bromophenyl)ethyl]-1-piperazinyl}-2-methylquinolineAusbeute 56 %

Versuchsvorschrift

The title compound was prepared in 56% yield using a similar procedure to description D5 starting from 2-methyl-5-(1-piperazinyl)quinoline (D3) and 2-(3-bromophenyl)ethyl methanesulfonate (D13).

Quellen und Nachweise

ORD-Eintrag
ord-5db34a42240e480c884c3e96136bf5ea
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732600B2

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