2-Methyl-5-(4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline → 7-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinoline

HRID 15782

Reaktionsgleichung

Reaktionsgleichung von HRID 15782
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-:28])=[O:27])[CH:21]=3)[CH2:14][CH2:13]2)[N:3]=1.[Cl:29]C1C=C2C(C=CC(C)=N2)=C(N2CCNCC2)C=1.[N+](C1C=CC(S(OCCC2C=CC=C([N+]([O-])=O)C=2)(=O)=O)=CC=1)([O-])=O>>[Cl:29][C:6]1[CH:5]=[C:4]2[C:9]([CH:10]=[CH:11][C:2]([CH3:1])=[N:3]2)=[C:8]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-:28])=[O:27])[CH:21]=3)[CH2:14][CH2:13]2)[CH:7]=1

Komponenten

4

Edukt 3

HCID 498519022-Methyl-5-(4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinolineHCID 574442742-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonateHCID 574442757-Chloro-2-methyl-5-piperazin-1-ylquinoline

Produkt 1

HCID 574442767-Chloro-2-methyl-5-{4-[2-(3-nitrophenyl)ethyl]-1-piperazinyl}quinolineAusbeute 92 %

Versuchsvorschrift

The title compound was prepared in 92% yield using a similar procedure to description D5 starting from 7-chloro-2-methyl-5-(1-piperazinyl)quinoline (D16) and 2-(3-Nitrophenyl)ethyl 4-nitrobenzenesulfonate (D15).

Quellen und Nachweise

ORD-Eintrag
ord-1a371ec5f0954aadba4ca9cc774c215b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732600B2

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