HCID 178524696, Verbindung → HCID 178516363, Verbindung
Reaktionsgleichung
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:14][CH2:13][O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][C:3]=1C(O)=O>N1C2C(=CC=CC=2)C=CC=1>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:14][CH2:13][O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][CH:3]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 17 g (73 mmoles) of 4-hydroxy-6,7-methylenedioxyquinoline-3-carboxylic acid, ref. 3 g, of Cu powder and 100 ml of quinoline was heated at reflux for one-half hour at an internal temperature of 235°-240°. The mixture was filtered, cooled and diluted with 250 ml of Skelly C. Filtration of the resultant precipitate yielded a light brown solid, mp 276°-279° dec. Recrystallizations from EtOH gave 9.1 g of the quinoline, mp 280°-281° C dec. ref. D. Kaminsky and R. I. Meltzer, U.S. Pat. No. 3,287,458. (Nov. 22, 1966) [Chem. abstr. 66, 65399 u (1967)].