7,8-Dichloroisoquinoline--hydrogen chloride (1/1) → Isoquinoline, 7,8-dichloro-1,2,3,4-tetrahydro-

HRID 1578704Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1578704
Cl.[Cl:2][C:3]1[C:12]([Cl:13])=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[CH:10]2)=[CH:5][CH:4]=1>[Pt]=O.CO>[Cl:2][C:3]1[C:12]([Cl:13])=[C:11]2[C:6]([CH2:7][CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 1

HCID 125950637,8-Dichloroisoquinoline--hydrogen chloride (1/1)

Produkt 1

HCID 123920Isoquinoline, 7,8-dichloro-1,2,3,4-tetrahydro-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The above prepared 7,8-dichloroisoquinoline hydrochloride was reduced in two portions, using 0.7 g. of platinum oxide in 100 cc. of methanol, for 1 hour at ambient temperature. The mixture was filtered and concentrated. The residue was converted to the base using ammonium hydroxide and was extracted into ether. The extract was dried with magnesium sulfate, filtered and concentrated to give, as the residue, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. extractionwas extracted into ether
  4. dry with materialThe extract was dried with magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d8896014b206426587dc63f8529baba7
Quelldatensatz
uspto-grants-1976_02
Patentnummer
US03939164

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