Propylamine → 2-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

HRID 1579427Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1579427
[CH2:1]([O:3][C:4]1[N:5]=[C:6](OCC)[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2].[CH2:16]([NH2:19])[CH2:17][CH3:18]>C(O)C>[CH2:1]([O:3][C:4]1[N:5]=[C:6]([NH:19][CH2:16][CH2:17][CH3:18])[C:7]2[C:8](=[CH:10][S:11][CH:12]=2)[N:9]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 7852PropylamineHCID 21568428HCID 21568428, Verbindung

Produkt 1

HCID 215684642-Ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2.3 g (0.01 mole) of 2,4-diethoxy-thieno[3,4-d]pyrimidine and 3.6 g (0.06 mole) of n-propylamine in 50 ml absolute ethyl alcohol is heated under reflux for 10 hours. The solution is then evaporated to dryness. The solid is drained off, washed with water and dried. After recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine are obtained. M.P. 140°-142°C.

Aufarbeitung

  1. temperatureunder reflux for 10 hours
  2. customThe solution is then evaporated to dryness
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization from toluene, 14 g (59% of theory) of 2-ethoxy-4-n-propylamino-thieno[3,4-d]pyrimidine
  6. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-98122460a0e44fd8860c40a40c6481f6
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03931204

Notizen zur Reaktion

Wird geladen…