5-Aminosalicylic Acid → HCID 12270313, Verbindung

HRID 1579906Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1579906
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH2:12][C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=O)[C:7](=O)[CH2:6][CH2:5]2.[NH2:22][C:23]1[CH:31]=[C:27]([C:28]([OH:30])=[O:29])[C:26]([OH:32])=[CH:25][CH:24]=1.CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O>>[C:28]([C:27]1[CH:31]=[C:23]([N:22]2[C:7]3[CH2:6][CH2:5][C:4]4[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:9]=4[C:8]=3[CH:12]=[C:13]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:24]=[CH:25][C:26]=1[OH:32])([OH:30])=[O:29]

Komponenten

4

Edukt 3

HCID 40755-Aminosalicylic AcidHCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 122703422(1H)-Naphthalenone, 6-chloro-3,4-dihydro-1-(2-oxo-2-phenylethyl)-

Produkt 1

HCID 12270313HCID 12270313, Verbindung

Versuchsvorschrift

A mixture of 10.1 g. (0.03 mole) of 6-chloro-1-phenacyl-2-tetralone, 4.5 g. (0.03 mole) of 5-aminosalicylic acid and 30 ml. of glacial acetic was heated under reflux for 70 minutes, cooled and filtered. The collected solid was washed with acetic acid and petroleum ether and recrystallized from acetonitrile to give 4.3 g. (59%) of colorless crystals, m.p. 249°-251°.

Aufarbeitung

  1. additionA mixture of 10.1 g
  2. temperatureunder reflux for 70 minutes
  3. temperaturecooled
  4. filtrationfiltered
  5. washThe collected solid was washed with acetic acid and petroleum ether
  6. customrecrystallized from acetonitrile
  7. customto give 4.3 g

Quellen und Nachweise

ORD-Eintrag
ord-520cfdc009d849d29f7d7af0ad47a115
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03931407

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