Hydrochloric Acid → HCID 70637301, Verbindung

HRID 1580238Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1580238
[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1.[OH-].[K+].[ClH:29].[Cl-].[Na+]>CO.O>[ClH:29].[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 18594875HCID 18594875, Verbindung

Produkt 1

HCID 70637301HCID 70637301, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

A solution of 1 g. of ethyl 15-amino-9-oxo-prostanoate (Example 143) in 15 ml. of methanol-water (1:1) containing 445 mg. of potassium hydroxide is stirred at ambient temperature for 18 hours. The solution is acidifed with hydrochloric acid, saturated with sodium chloride, and extracted several times with methylene chloride. The organic phase is dried with anhydrous magnesium sulfate and taken to dryness to give a viscous oil; λ max. 2.80 - 3.70 (broad), 5.75, and 5.87 μ.

Aufarbeitung

  1. extractionextracted several times with methylene chloride
  2. dry with materialThe organic phase is dried with anhydrous magnesium sulfate
  3. customto give a viscous oil

Quellen und Nachweise

ORD-Eintrag
ord-e7f969c7bf5f4de29d0239e1cfc7bc11
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03932472

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