1,5-dimethyl-1H-pyrazole-3-carboxylic acid → 1,5-Dimethyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-pyrazole-3-carboxamide

HRID 15804

Reaktionsgleichung

Reaktionsgleichung von HRID 15804
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=3)[NH2:23])[CH2:14][CH2:13]2)[N:3]=1.[CH3:27][N:28]1[C:32]([CH3:33])=[CH:31][C:30]([C:34](O)=[O:35])=[N:29]1>>[CH3:27][N:28]1[C:32]([CH3:33])=[CH:31][C:30]([C:34]([NH:23][C:22]2[CH:24]=[CH:25][CH:26]=[C:20]([CH2:19][CH2:18][N:15]3[CH2:14][CH2:13][N:12]([C:8]4[CH:7]=[CH:6][CH:5]=[C:4]5[C:9]=4[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]5)[CH2:17][CH2:16]3)[CH:21]=2)=[O:35])=[N:29]1

Komponenten

3

Edukt 2

HCID 5877571,5-dimethyl-1H-pyrazole-3-carboxylic acidHCID 498521053-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

Produkt 1

HCID 684266031,5-Dimethyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1H-pyrazole-3-carboxamideAusbeute 35 %

Versuchsvorschrift

The title compound was prepared in 35% yield according to the general procedure for the preparation of the amides (Method C) starting from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 1,5-dimethyl-1H-pyrazole-3-carboxylic acid.

Quellen und Nachweise

ORD-Eintrag
ord-68e9b4658a2245649478087ecffe641e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732600B2

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