Ammonia → Cyclopentylurea

HRID 1580464

Reaktionsgleichung

Reaktionsgleichung von HRID 1580464
C1(=N[NH:10][C:11](N)=[O:12])CCCCCCC1.[CH:14]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15]1.N>O1CCOCC1>[CH:14]1([NH:19][C:11](=[O:12])[NH2:10])[CH2:18][CH2:17][CH2:16][CH2:15]1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 2906CyclopentylamineHCID 3348066Cyclooctanone semicarbazone

Produkt 1

HCID 294526Cyclopentylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

1.8 g of 4-[4-(β-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-cyclooctanone-semicarbazone, 50 ml of dioxane and 0.29 g of cyclopentyl-amine were refluxed for 1 hour. The clear solution was concentrated in vacuo and the residue obtained was treated with about 0.5 %-aqueous ammonia. After filtration the filtrate was acidified. A crystalline precipitate of N-[4-(β-<2-methoxy-5-chlorobenzamido>-ethyl)-benzenesulfonyl]-N'-cyclopentyl-urea was obtained, separated by suction-filtration, dried and recrystallized from methanol. The melting point of the substance was 182° - 184°C.

Aufarbeitung

  1. concentrationThe clear solution was concentrated in vacuo
  2. customthe residue obtained
  3. filtrationAfter filtration the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-89c5288613194b2bb0053f6c99037581
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03932658

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