L-Prolinamide → HCID 12807324, Verbindung

HRID 1580888Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1580888
[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([NH2:5])=[O:4].[CH3:9][C@H:10]([NH:23][C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25])[C:11](OC1C=CC([N+]([O-])=O)=CC=1)=[O:12]>CN(C)C=O>[NH:23]([C:24]([O:26][CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)=[O:25])[C@H:10]([C:11]([N:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([NH2:5])=[O:4])=[O:12])[CH3:9]

Komponenten

4

Edukt 2

HCID 111306L-ProlinamideHCID 7021878Z-Ala-ONp

Produkt 1

HCID 12807324HCID 12807324, VerbindungAusbeute 86,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2.28 g of H-Pro-NH2 and 7.57 g of Z-Ala-ONP are dissolved in 20 ml of dimethylformamide and the yellow solution is left standing at room temperature for 18 hours. It is then evaporated to dryness in a high vacuum, the residue is mixed with ether and the resulting powder is thoroughly triturated. After filtering off and drying, 5.5 g of Z-Ala-Pro-NH2 of melting point 167.5°-168.5°C are obtained. [α]D20 = -74° (c =1 in methanol).

Aufarbeitung

  1. waitthe yellow solution is left
  2. customIt is then evaporated to dryness in a high vacuum
  3. additionthe residue is mixed with ether
  4. customthe resulting powder is thoroughly triturated
  5. filtrationAfter filtering off
  6. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-d6af3758ca6748e7bba682dab36a5779
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03934008

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