Ammonia → 5-(3,4-Dibromobutyl)pyridine-2-carboxamide

HRID 1580973

Reaktionsgleichung

Reaktionsgleichung von HRID 1580973
[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11](O)=[O:12])=[N:9][CH:10]=1.[NH3:16]>C(O)C.Cl>[Br:1][CH:2]([CH2:14][Br:15])[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH2:16])=[O:12])=[N:9][CH:10]=1

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 2167205-(3,4-Dibromobutyl)pyridine-2-carboxylic acid

Produkt 1

HCID 132718775-(3,4-Dibromobutyl)pyridine-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

10 g of 5-(3,4-dibromobutyl)picolinic acid was dissolved in 200 ml of ethanol saturated with dry hydrochloride gas and resulting solution was refluxed for six hours. Reaction mixture was evaporated in reduced pressure and resulting pale yellow oil was dissolved in 300 ml of ethanol saturated with dry ammonia gas. The solution was kept to stand at room temperature for three days, and then evaporated in reduced pressure. Resulting solid was crystallized from benzene to give 6.5 g of the pure product as platelets.

Aufarbeitung

  1. customresulting solution
  2. temperaturewas refluxed for six hours
  3. customReaction mixture
  4. customwas evaporated in reduced pressure
  5. customresulting pale yellow oil
  6. customevaporated in reduced pressure
  7. customResulting solid
  8. customwas crystallized from benzene

Quellen und Nachweise

ORD-Eintrag
ord-dcd86b428b6948b8a5f064103ab4adad
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03935221

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