Reaktionsgleichung
C(OC([N:11]1[CH2:15][CH:14]([O:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:13][N:12]1[C:23](=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=1)=O)C1C=CC=CC=1>CO>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][C:23]([N:12]2[CH2:13][CH:14]([O:16][C:17](=[O:22])[C:18]([CH3:20])([CH3:19])[CH3:21])[CH2:15][NH:11]2)=[O:32])=[CH:26][CH:27]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-[2-(4-Fluorophenyl)acetyl]-4-(2,2-dimethylpropionyloxy)-pyrazolidine-1-carboxylic acid 1-benzyl ester, 31, (1.71 g, 3.86 mmol) is dissolved in methanol (40 mL). The flask is flushed with nitrogen and charged with 10% palladium on carbon (300 mg). The reaction flask is stirred vigorously at room temperature under 1 atmosphere of hydrogen gas for 6 hours. The flask is flushed with nitrogen and the reaction mixture filtered through a pad of Celite, rinsing with ethyl acetate (100 mL). The filtrate is concentrated in vacuo to afford 1.18 g (98% yield) of the desired product as a tan solid.
Aufarbeitung
- customThe flask is flushed with nitrogen
- additioncharged with 10% palladium on carbon (300 mg)
- customThe flask is flushed with nitrogen
- filtrationthe reaction mixture filtered through a pad of Celite
- washrinsing with ethyl acetate (100 mL)
- concentrationThe filtrate is concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-186dfad7dea84dd8a7008fa6e3628fba
- Quelldatensatz
- uspto-grants-2004_05
- Patentnummer
- US06730668B2
Verknüpfte Notizen
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