4-Oxazolin-2-one → HCID 178511990, Verbindung

HRID 1581910

Reaktionsgleichung

Reaktionsgleichung von HRID 1581910
O1C=CNC1=O.[C:7]1([NH:13][C:14]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)=[NH:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(O[CH:25]=[C:26]1[C:30](=[O:31])[O:29][C:28]([C:32]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:35]=[CH:34][CH:33]=2)=[N:27]1)C>CS(C)=O>[C:32]1([C:28]2[O:29][C:30](=[O:31])[C:26](=[CH:25][N:19]3[CH2:20][CH2:21][N:16]([C:14]([NH:13][C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[NH:15])[CH2:17][CH2:18]3)[N:27]=2)[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:35]=[CH:34][CH:33]=1

Komponenten

5

Edukt 3

HCID 1861144-Oxazolin-2-oneHCID 3569304-ethoxymethylene-2-(1)-naphthyl-5(4H)-oxazoloneHCID 178511989HCID 178511989, Verbindung

Produkt 1

HCID 178511990HCID 178511990, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel2×

Versuchsvorschrift

4-(2-Naphthalen-1-yl-5-oxo-oxazol-4-ylidenemethyl)-N-phenyl-piperazine-1-carboxamidine was prepared as described in commonly owned U.S. patent applications U.S. S.No. 60/124,781; filed on Mar. 17, 1999; U.S. S.No. 60/165,312, filed on Nov. 12, 1999; and U.S. Ser. No. 09/521,185, filed Mar. 8, 2000 by Coffen, et al. entitled “Oxazolone Derivatives and Uses Thereof”, filed herewith. Briefly, to a 0.25 M solution of N-phenyl-piperazine-1-carboxamidine (200 μL, 50 μmole) was added a 0.25 M solution of 4-ethoxymethylene-2-naphthalene-1-yl-4H-oxazol-5-one in DMSO (200 μL, 25 μmole). The reaction vessel was sealed and the resulting mixture shaken at room temperature for 1 h to yield the desired product as a DMSO solution (MH+426).

Aufarbeitung

  1. customThe reaction vessel was sealed

Quellen und Nachweise

ORD-Eintrag
ord-6457fcbfcb904f77915d8ebc439fdeb8
Quelldatensatz
uspto-grants-2004_05
Patentnummer
US06733982B1

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