Formamide → HCID 178518069, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)[C:6]=1[C:7](OCC)=[O:8].[CH:17]([NH2:19])=O>>[O:13]1[CH:14]=[CH:15][CH:16]=[C:12]1[C:5]1[C:6]2[C:7]([OH:8])=[N:19][CH:17]=[N:1][C:2]=2[S:3][CH:4]=1Komponenten
3
Versuchsvorschrift
Ethyl 2-amino-4-(2-furyl)thiophene-3-carboxylate (500 mg, 2.1 mmol) in formamide (4 ml) was stirred at 180° C. for 3 hours. The precipitate obtained by cooling the reaction mixture was filtered to obtain 5-(2-furyl)-4-hydroxythieno[2,3-d]pyrimidine (330 mg, 1.5 mmol) having the following physical properties:
Aufarbeitung
- customThe precipitate obtained
- temperatureby cooling the reaction mixture
- filtrationwas filtered
Quellen und Nachweise
- ORD-Eintrag
- ord-c2a1d40642044667983c048b07118d7f
- Quelldatensatz
- uspto-grants-2004_05
- Patentnummer
- US06734180B1
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