1-Iodopropane → 8-Bromo-6-isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline

Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[C:4]([CH:14]([CH3:16])[CH3:15])[CH:5]=[C:6]2[C:11]=1[NH:10][CH2:9][CH2:8][C:7]2([CH3:13])[CH3:12].I[CH2:18][CH2:19][CH3:20]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:14]([CH3:16])[CH3:15])[CH:5]=[C:6]2[C:11]=1[N:10]([CH2:18][CH2:19][CH3:20])[CH2:9][CH2:8][C:7]2([CH3:12])[CH3:13]

Komponenten

Edukt 2

HCID 336431-Iodopropane

HCID 227198208-Bromo-6-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline2×

Produkt 1

HCID 227198378-Bromo-6-isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline

Versuchsvorschrift

Following General Procedure A, 8-bromo-6-isopropyl-4,4-dimethyl-1-alkyl-1,2,3,4-tetrahydro-quinoline (Intermediate 4, 3.0 g, 9.1 mmol) and 1-iodopropane (5.2 g, 46 mmol) were reacted to produce the title compound as a yellow oil.

Aufarbeitung

customwere reacted

Quellen und Nachweise

ORD-Eintrag: ord-0bebe608d2aa4ee69c1ed8699d2516c6
Quelldatensatz: uspto-grants-2004_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06734193B1

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