2-Methoxyethylamine → Methyl 4,7-dihydro-5-(2-methoxyethyl)amino-4,7-dioxobenzo[b]thiophene-2-carboxylate
Reaktionsgleichung
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[O:6]=[C:7]1[C:15]2[CH:14]=[C:13]([C:16]([O:18][CH3:19])=[O:17])[S:12][C:11]=2[C:10](=[O:20])[CH:9]=[CH:8]1>O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:8]1[C:7](=[O:6])[C:15]2[CH:14]=[C:13]([C:16]([O:18][CH3:19])=[O:17])[S:12][C:11]=2[C:10](=[O:20])[CH:9]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-Methoxyethylamine (1.6 ml) was added to a solution of methyl 4,7-dihydro-4,7-dioxobenzo[b]thiophene-2-carboxylate (2.4 g) in tetrahydrofuran (100 ml) and the mixture was stirred at room temperature for 27 hours. After evaporation of the solvent, the residue was purified by silica gel column chromatography (elution with chloroform) to give methyl 4,7-dihydro-5-(2-methoxyethyl)amino-4,7-dioxobenzo[b]thiophene-2-carboxylate (1.5 g) as a yellow powder.