Hydrochloric Acid → Ethyl 2,4-dimethoxy-benzimidate hydrochloride

HRID 1582461

Reaktionsgleichung

Reaktionsgleichung von HRID 1582461
[ClH:1].[CH3:2][O:3][C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7].[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[C:6](=[NH:7])[O:16][CH2:14][CH3:15]

Komponenten

4

Edukt 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 777502,4-Dimethoxybenzonitrile

Produkt 1

HCID 22721088Ethyl 2,4-dimethoxy-benzimidate hydrochlorideAusbeute 57 %

Versuchsvorschrift

Hydrogen chloride gas was passed through a solution of 2,4-dimethoxy-benzonitrile (5.20 g, 32 mmol) in anhydrous ethanol (200 mL) at 0° C. After 7 h, hydrogen chloride gas was stopped and the reaction mixture was stirred at room temperature overnight. The solvent was removed and the residue was triturated in diethyl ether to afford ethyl 2,4-dimethoxy-benzimidate hydrochloride (4.5 g, 57%). It was used without further purification.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue was triturated in diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-8df2d3d2fdad44ba9f89268a3002e98f
Quelldatensatz
uspto-grants-2004_05
Patentnummer
US06734302B2

Verknüpfte Notizen

Wird geladen…