Trifluoroacetic acid → HCID 69929667, Verbindung

HRID 1582741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1582741
C(O[C:6](=O)[N:7]([C@H:9]([C:25](=[O:38])[NH:26][CH2:27][C:28]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:31][CH2:30][CH2:29]1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)C)(C)(C)C.[C:40]([OH:46])([C:42]([F:45])([F:44])[F:43])=[O:41]>C(Cl)Cl>[F:43][C:42]([F:45])([F:44])[C:40]([OH:46])=[O:41].[CH2:18]([O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][C@H:9]([NH:7][CH3:6])[C:25]([NH:26][CH2:27][C:28]2([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:29][CH2:30][CH2:31]2)=[O:38])=[CH:12][CH:13]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69927875HCID 69927875, Verbindung

Produkt 1

HCID 69929667HCID 69929667, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (S)-{2-(4-Benzyloxy-phenyl)-1-[(1-phenyl-cyclobutylmethyl)-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (from Step 1; 1.07 g, 2.02 mmol) in methylene chloride (10 mL) was added TFA (2.5 mL). The solution was stirred at room temperature for 2 hours and then concentrated in vacuo. Coevaporisation with methylene chloride was carried out twice to give the desired product which was used without further purification.

Aufarbeitung

  1. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6400e92f43bb4cb3a24dfc812ceaf6e6
Quelldatensatz
uspto-grants-2004_05
Patentnummer
US06737410B1

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