Ammonia → 5-(Chloromethyl)isoxazole-3-carboxamide

Temperatur

0 °C

Ammonia was passed for 1 hour at 10-15° C. into a solution of 10 g (55.56 mmol) of 5-chloromethylisoxazole-3-carboxylic acid chloride in 100 ml of methylene chloride and stirring was subsequently continued at room temperature for 1 hour. After the solution had cooled to 0° C., the precipitate was filtered off with suction and washed with a little cold methylene chloride, and the residue was extracted twice by stirring with water to remove the ammonium salts. Drying in vacuo resulted in 6.58 g of pure product as a pale powder (74% of theory)

1. filtrationthe precipitate was filtered off with suction
2. washwashed with a little cold methylene chloride
3. extractionthe residue was extracted twice
4. stirringby stirring with water
5. customto remove the ammonium salts
6. customDrying in vacuo

ORD-Eintrag

ord-ef335c7c91cc47a196ed1e8cd5354d4f

Quelldatensatz

uspto-grants-2004_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06740647B1