2-(Benzyloxy)-5-formylbenzoic acid → 2-(2,4-Difluorobenzyloxy)-5-formylbenzoic acid
Reaktionsgleichung
[F:1][C:2]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:3]=1[CH2:4][O:5][C:6]1[CH:23]=[CH:22][C:21]([CH:24]=[O:25])=[CH:20][C:7]=1[C:8]([O:10]CC1C=CC(F)=CC=1F)=[O:9].C(OC1C=CC(C=O)=CC=1C(O)=O)C1C=CC=CC=1>>[F:1][C:2]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:3]=1[CH2:4][O:5][C:6]1[CH:23]=[CH:22][C:21]([CH:24]=[O:25])=[CH:20][C:7]=1[C:8]([OH:10])=[O:9]Komponenten
3
Versuchsvorschrift
2-(2,4-Difluorobenzyloxy)-5-formylbenzoic acid was prepared from 2,4-difluorobenzyl 2-(2,4-difluorobenzyloxy)-5-formylbenzoate (1.2 g, 1 eq) using the same procedure as for 2-benzyloxy-5-formylbenzoic acid. The product was obtained as a white powder (746 mg, 89%). 1H NMR (CDCl3) δ9.97 (s, 1H, O═C—H), 5.37 (s, 2H, CH2Ar).
Quellen und Nachweise
- ORD-Eintrag
- ord-1890d1b8896f4c0d8b3c55aff15e654f
- Quelldatensatz
- uspto-grants-2004_05
- DOI