Anthranilic Acid → N-Methylanthranilic acid

HRID 1583248

Reaktionsgleichung

Reaktionsgleichung von HRID 1583248
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:11]=O.[H][H]>C(O)C.[Pt]=O>[CH3:11][NH:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

6

Edukt 3

HCID 227Anthranilic AcidHCID 712FormaldehydeHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 67069N-Methylanthranilic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-aminobenzoic acid (25 g) in ethanol (300 ml) reacted with an excess of paraformaldehyde and then reduced with hydrogen gas at 60 psi over platinum oxide (25 g) catalyst. After hydrogen uptake ceased, the mixture was filtered and the solvent removed on a rotary evaporator. The product was purified by chromatography on silica gel and the structure confirmed by nmr and infrared analysis.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. customthe solvent removed on a rotary evaporator
  3. customThe product was purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-ed246f2e1c7046a1a8e4929d902ad398
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04551279

Verknüpfte Notizen

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