Sodium Hydroxide → 7-(Pyridin-3-yl)heptan-1-amine

HRID 1583422Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1583422
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)C)[CH:2]=1.[OH-].[Na+]>Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH:2]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 13557529N-[7-(Pyridin-3-yl)heptyl]acetamide

Produkt 1

HCID 135575307-(Pyridin-3-yl)heptan-1-amineAusbeute 81,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 5.1 g of N-[7-(3-pyridyl)heptyl]acetamide was heated to reflux in diluted hydrochloric acid overnight. The mixture was cooled, made basic with 50% sodium hydroxide solution and was extracted with dichloromethane. The combined organic layers were dried over potassium carbonate and were evaporated. The residue was distilled to give 3.4 g of 3-pyridine heptanamine, bp 175°-180° C./0.4 mm.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. extractionwas extracted with dichloromethane
  3. dry with materialThe combined organic layers were dried over potassium carbonate
  4. customwere evaporated
  5. distillationThe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-3805197ade654298a29bb3b30b38035f
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04551460

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