HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Iodoethane → (alphaS)-3-ethyl-3-(mercaptomethyl)-alpha-methyl-2-oxo-1-pyrrolidineacetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Iodoethane | HCID 6340 | — |
| Edukt | Benzylthiobromomethane | HCID 4067177 | — |
| Edukt | (S)-2-(2-oxopyrrolidin-1-yl)propanoic acid | HCID 7175678 | — |
| Produkt | (alphaS)-3-ethyl-3-(mercaptomethyl)-alpha-methyl-2-oxo-1-pyrrolidineacetic acid | HCID 18600216 | — |
Reaktionsschritte
Following the procedures of Examples 1C-1E, α(S)-methyl-2-oxo-1-pyrrolidineacetic acid was first alkylated with ethyl iodide and then with benzylmercaptomethyl bromide. Removal of the benzyl group in the usual way and purification by chromatography provided the title compound as a mixture of diastereomers. [α]D25 =-4.04° (c=1, methanol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04552889 |
| Quelldatensatz | uspto-grants-1985_11 |
| ORD ID | ord-f5282b269af4496fb176721b5249d416 |
| Quellennotiz | uspto-grants-1985_11 |