2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoroindole

HRID 1583607

Reaktionsgleichung

Reaktionsgleichung von HRID 1583607
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1SC)=[C:8]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)[C:7]([F:19])=[CH:6][C:5]=2Br>[Ni].C(O)C>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1)[C:7]([F:19])=[CH:6][CH:5]=2

Komponenten

4

Edukt 1

HCID 202589822-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole

Produkt 1

HCID 202589922-Methyl-4-morpholino-5-fluoroindoleAusbeute 72,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Raney nickel (1.5 kg) was added to a solution of 214 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 3 l of ethanol and the mixture was refluxed for 3 hours. After completion of reaction the reaction mixture was cooled and Raney nickel was removed by filtration. Concentration of the filtrate gave 101 g of 2-methyl-4-morpholino-5-fluoroindole.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 3 hours
  2. customAfter completion of reaction the reaction mixture
  3. temperaturewas cooled
  4. customRaney nickel was removed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-caa16cf72c86432aa7a8903bd47b80c2
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04552879

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