1-Chloro-2-methylpropan-2-amine → N-carbobenzyloxi-gamma-tert.butyl-L-glutamic acid-dimethylaminoethyl ester

HRID 1583668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1583668
[CH:1]1([NH2+:7][CH:8]2[CH2:13]CCCC2)CCCCC1.[C:14]([NH:24][C@H:25]([C:35]([O-:37])=[O:36])[CH2:26][CH:27]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:28]([O-:30])=[O:29])([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].[CH:38]1([NH2+:44][CH:45]2[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46]2)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1.CC(C)(N)C[Cl:54]>>[CH3:38][N:7]([CH2:8][CH2:13][O:36][C:35](=[O:37])[C@H:25]([CH2:26][CH:27]([C:31]([CH3:32])([CH3:33])[CH3:34])[C:28]([OH:30])=[O:29])[NH:24][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[CH3:1].[Cl-:54].[CH:45]1([NH2+:44][CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]1

Komponenten

4

Edukt 2

HCID 4077261-Chloro-2-methylpropan-2-amineHCID 131714411N-carbobenzyloxy-gamma-tert.butyl-L-glutamic acid-dicyclohexyl ammonium salt

Produkt 2

HCID 56625707N-carbobenzyloxi-gamma-tert.butyl-L-glutamic acid-dimethylaminoethyl esterHCID 69082364Dicyclohexylammonium chloride

Versuchsvorschrift

In said first step, N-carbobenzyloxy-γ-tert.butyl-L-glutamic acid-dicyclohexyl ammonium salt suspended in the organic solvent is reacted with dimethyl-aminoethylchloride in the solution to form N-carbobenzyloxi-γ-tert.butyl-L-glutamic acid-dimethylaminoethyl ester (Intemediate I) and dicyclohexyl-ammonium chloride to be precipitated.

Quellen und Nachweise

ORD-Eintrag
ord-1f2a292f06c24b129509cbfacf666801
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04552975

Notizen zur Reaktion

Wird geladen…