Sulfuric acid magnesium salt (1:1) → 2-Methyl-2,3-dihydrobenzofuran-7-amine

HRID 1583750Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1583750
[CH3:1][CH:2]1[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1.[H][H].S([O-])([O-])(=O)=O.[Mg+2]>[Ni].O1CCCC1>[NH2:11][C:10]1[C:4]2[O:3][CH:2]([CH3:1])[CH2:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

Komponenten

6

Edukt 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 135358252,3-Dihydro-2-methyl-7-nitrobenzofuranHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 135358262-Methyl-2,3-dihydrobenzofuran-7-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 81 g of 1B, 400 ml of tetrahydrofuran (THF) and 3 g of activated Raney nickel catalyst was shaken under 35 p.s.i.g. hydrogen pressure at room temperature for 4 hours. The resulting mixture was treated with 20 g of magnesium sulfate, filtered and the solvent was evaporated from the filtrate, to give 7-amino-2,3-dihydro-2-methylbenzofuran (1C), as an amber syrup.

Aufarbeitung

  1. filtrationfiltered
  2. customthe solvent was evaporated from the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-12053be2ae1a4bbe8cc39785391c23c4
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04554283

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