1-Bromohexadecane → HCID 13076757, Verbindung

HRID 1583919Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1583919
[C:1]([C:5]1[C:14]([OH:15])=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:22](Br)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>CN(C)C=O>[C:1]([C:5]1[C:14]([O:15][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH3:22])=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 82131-BromohexadecaneHCID 11430Potassium CarbonateHCID 12886750HCID 12886750, Verbindung

Produkt 1

HCID 13076757HCID 13076757, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

6.9 g of the benzoxazole derivative obtained in Step (c) above was dissolved in 50 ml of dimethylformamide and the solution was stirred at 80° to 90° C. for 6 hours together with 8 g of anhydrous potassium carbonate and 11 g of hexadecyl bromide. After the completion of the reaction, the insoluble material was removed by filtration. To the filtrate was added 150 ml of methanol and the mixture was cooled with ice to precipitate crystals. The crystals were collected by filtration, thus obtained 8.8 g (62%) yield) of 6-tert-butyl-5-hexadecyloxy-2-methylbenzoxazole.

Aufarbeitung

  1. customAfter the completion of the reaction
  2. customthe insoluble material was removed by filtration
  3. additionTo the filtrate was added 150 ml of methanol
  4. temperaturethe mixture was cooled with ice
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration, thus obtained 8.8 g (62%)

Quellen und Nachweise

ORD-Eintrag
ord-de0d5940eb88473c8abcbf0953c28cc7
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04555470

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