Acetonitrile → 2-Methylquinazoline

HRID 1584136

Reaktionsgleichung

Reaktionsgleichung von HRID 1584136
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Komponenten

3

Edukt 2

HCID 6342AcetonitrileHCID 760802-Aminobenzophenone

Produkt 1

HCID 5889872-Methylquinazoline

Versuchsvorschrift

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Quellen und Nachweise

ORD-Eintrag
ord-2154f7d610e34b06b569829eff29d7de
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05932592

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