Hydrochloric Acid → 1,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide hydrochloride

HRID 1584269Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1584269
[C:1]([C:3]1[CH:36]=[CH:35][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([C@@H:18]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][N:19]3C(OC(C)(C)C)=O)=[O:17])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].[ClH:37]>CCOC(C)=O>[ClH:37].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([C@@H:18]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][NH:19]3)=[O:17])=[CH:11][N:10]=[CH:9]2)=[CH:35][CH:36]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 701032202-(t-Butyloxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide

Produkt 1

HCID 701220621,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A solution of 2-(t-butyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide (0.25 g, 0.52 mmol) in EtOAc (15 mL) was cooled to -20° C. The solution was saturated with HCl gas and stirred at 0° C. for 0.5 hr and 25° C. for an additional 0.5 hr. The reaction was evaporated in vacuo to obtain the title compound which was used without further purification.

Aufarbeitung

  1. customThe reaction was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3499189afff04f018e0f1f99021e9a43
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05932590

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