4-chloromethyl-2-[(E)-styryl]thiazole → 5-[3-[3-methoxy-4-[2-[(E)-styryl]-4-thiazolylmethoxy]-phenyl]propyl]-2,4-oxazolidinedione

HRID 1584299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1584299
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]2[O:15][C:14](=[O:16])[NH:13][C:12]2=[O:17])=[CH:4][C:3]=1[O:18][CH3:19].Cl[CH2:21][C:22]1[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[S:25][CH:26]=1>>[CH3:19][O:18][C:3]1[CH:4]=[C:5]([CH2:8][CH2:9][CH2:10][CH:11]2[O:15][C:14](=[O:16])[NH:13][C:12]2=[O:17])[CH:6]=[CH:7][C:2]=1[O:1][CH2:21][C:22]1[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[S:25][CH:26]=1

Komponenten

3

Edukt 2

HCID 220097354-chloromethyl-2-[(E)-styryl]thiazoleHCID 698304715-[3-(4-Hydroxy-3-methoxyphenyl)propyl]-2,4-oxazolidinedione

Produkt 1

HCID 698309395-[3-[3-methoxy-4-[2-[(E)-styryl]-4-thiazolylmethoxy]-phenyl]propyl]-2,4-oxazolidinedione

Versuchsvorschrift

In substantially the same manner as in Working Example 9, 5-[3-(4-hydroxy-3-methoxyphenyl)propyl]-2,4-oxazolidinedione was allowed to react with 4-chloromethyl-2-[(E)-styryl]thiazole to yield 5-[3-[3-methoxy-4-[2-[(E)-styryl]-4-thiazolylmethoxy]-phenyl]propyl]-2,4-oxazolidinedione. The product was recrystallized from chloroform-methanol to give colorless prisms, m.p.202-203° C.

Quellen und Nachweise

ORD-Eintrag
ord-e0644545b89c41b5b56956141ad7697b
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05932601

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