5-(Chloromethyl)-3-phenyl-1,2,4-oxadiazole → 5-[3-[3-Methoxy-4-(3-phenyl-1,2,4-oxadiazol-5-ylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

HRID 1584318

Reaktionsgleichung

Reaktionsgleichung von HRID 1584318
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]2[O:15][C:14](=[O:16])[NH:13][C:12]2=[O:17])=[CH:4][C:3]=1[O:18][CH3:19].Cl[CH2:21][C:22]1[O:26][N:25]=[C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:23]=1>>[CH3:19][O:18][C:3]1[CH:4]=[C:5]([CH2:8][CH2:9][CH2:10][CH:11]2[O:15][C:14](=[O:16])[NH:13][C:12]2=[O:17])[CH:6]=[CH:7][C:2]=1[O:1][CH2:21][C:22]1[O:26][N:25]=[C:24]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:23]=1

Komponenten

3

Edukt 2

HCID 9667145-(Chloromethyl)-3-phenyl-1,2,4-oxadiazoleHCID 698304715-[3-(4-Hydroxy-3-methoxyphenyl)propyl]-2,4-oxazolidinedione

Produkt 1

HCID 698300625-[3-[3-Methoxy-4-(3-phenyl-1,2,4-oxadiazol-5-ylmethoxy)phenyl]propyl]-2,4-oxazolidinedione

Versuchsvorschrift

In substantially the same manner as in Working Example 9, 5-[3-(4-hydroxy-3-methoxyphenyl)propyl]-2,4-oxazolidinedione was reacted with 5-chloromethyl-3-phenyl-1,2,4-oxadiazole to obtain 5-[3-[3-methoxy-4-(3-phenyl-1,2,4-oxadiazol-5-ylmethoxy)phenyl]propyl]-2,4-oxazolidinedione, which was recrystallized from ethyl acetate-hexane to give colorless prisms, m.p.110-111° C.

Quellen und Nachweise

ORD-Eintrag
ord-dd963909d9fc4e0f8fbdd368a63d1941
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05932601

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