Methylamine → 1-(6-Fluoropyridin-3-yl)-N-methylmethanamine

HRID 1585018Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585018
[CH3:1][NH2:2].[F:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10]Br)=[CH:6][CH:5]=1>CC#N>[F:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][NH:2][CH3:1])=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 220506385-(Bromomethyl)-2-fluoropyridine

Produkt 1

HCID 224503141-(6-Fluoropyridin-3-yl)-N-methylmethanamineAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a mixture of 2.5 g of 40% aqueous methylamine solution and 30 ml of CH3CN was added dropwise 3.0 g of crude (6-fluoro-3-pyridyl)methyl bromide with constant stirring. The mixture was allowed to stand at room temperature overnight and concentrated under reduced pressure. The residue was extracted with AcOEt and the extract was dried over MgSO4 and concentrated. The procedure gave 1.35 g of the title compound as a crude orange-colored oil.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. extractionThe residue was extracted with AcOEt
  3. dry with materialthe extract was dried over MgSO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-058e785b2242402ca630f02db8227006
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05935981

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