Methanol → HCID 54376030, Verbindung

HRID 1585463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585463
C[O:2][C:3]1[C:4]([CH3:14])=[C:5]([CH:10]=[CH:11][C:12]=1[CH3:13])[C:6]([O:8][CH3:9])=[S:7].B(Br)(Br)Br.CO>C(Cl)Cl>[OH:2][C:3]1[C:4]([CH3:14])=[C:5]([CH:10]=[CH:11][C:12]=1[CH3:13])[C:6]([O:8][CH3:9])=[S:7]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 25134Boron tribromideHCID 54217787HCID 54217787, Verbindung

Produkt 1

HCID 54376030HCID 54376030, VerbindungAusbeute 106,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

10 g (0.044 mol) of methyl 3-methoxy-2-methyl-4-methylthiobenzoate was dissloved in 90 ml of methylene chloride, and the solution was added dropwise to 90 ml of methylene chloride containing 8.4 ml (0.088 mol) of boron tribromide at 5 to 10° C. After stirring at room temperature for 4 hours, 50 ml of methanol was added dropwise under ice cooling, and the solution was then washed with water and next a saturated sodium chloride solution. After drying over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to obtain 9.2 g of methyl 3-hydroxy-2-methyl-4-methylthiobenzoate. Yield=98%.

Aufarbeitung

  1. washthe solution was then washed with water and next a saturated sodium chloride solution
  2. dry with materialAfter drying over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-82c2d973f58541229c898e5ce3141e02
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05939360

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