Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

HRID 1585903Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585903
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([OH:11])[CH:4]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CN(C=O)C>[OH:11][C:5]1[CH:4]=[C:3]([CH2:2][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

Komponenten

4

Edukt 2

HCID 795ImidazoleHCID 216969934-(Bromomethyl)-2-hydroxybenzonitrile

Produkt 1

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Bromomethyl-2-hydroxybenzonitrile (0.222 g, 1.045 mmol) and imidazole (0.356 g, 5.23 mmol) were stirred in DMF (10 mL) at ambient temperature for 18 hr. The reaction mixture was concentrated in vacuo to remove the DMF, and the residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2) to give the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto remove the DMF
  3. customthe residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-0a5f31d60b2a48a69cf2052e1752506b
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05939439

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