HCID 21696991, Verbindung → HCID 9823286, Verbindung

HRID 1585904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1585904
[OH:1][C:2]1[CH:9]=[C:8]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Br[CH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]2=[O:31])=[N:22][CH:23]=1>CN(C=O)C>[Cl:30][C:28]1[CH:27]=[CH:26][C:25](=[O:31])[N:24]([C:21]2[CH:20]=[CH:19][C:18]([CH2:17][O:1][C:2]3[CH:9]=[C:8]([CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)[CH:7]=[CH:6][C:3]=3[C:4]#[N:5])=[CH:23][N:22]=2)[CH:29]=1

Komponenten

4

Edukt 2

HCID 21696991HCID 21696991, VerbindungHCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

Produkt 1

HCID 9823286HCID 9823286, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-Hydroxy 4-imidazol-1-ylmethyl-benzonitrile (0.050 g, 0.25 mmol) and 5'-bromomethyl-5-chloro-[1,2']bipyridinyl-2-one (Example 10 Step 2) (0.079 g, 0.262 mmol) were dissolved in dry DMF (5 mL), treated with CsCO3 (0.123 g, 0.376 mmol) and stirred at ambient temperature for 18 hr. The reaction mixture was partitioned between EtOAc and aqueous satd NaHCO3 solution, the organic layer washed with H2O, brine, and dried (MgSO4). Chromatography (SiO2, 1-4% CH3OH in CH2Cl2) gave the title compound.

Aufarbeitung

  1. customThe reaction mixture was partitioned between EtOAc and aqueous satd NaHCO3 solution
  2. washthe organic layer washed with H2O, brine
  3. dry with materialdried (MgSO4)

Quellen und Nachweise

ORD-Eintrag
ord-03e0eeb813ac4be2a869433f1a6d05e4
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05939439

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