Chloride → HCID 45115680, Verbindung

HRID 1586535Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1586535
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].[Cl-]>CO>[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8]

Komponenten

4

Edukt 2

HCID 312ChlorideHCID 21217073Tert-butyl pyrazinecarboxylate

Produkt 1

HCID 45115680HCID 45115680, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Analogously to Example 4, 0.52 g (2.85 mmol) of tert-butyl pyrazinecarboxylate (prepared according to Example 2), 25.3 mg (54 μmol) of bicyclo[2.2.1 ]hepta-2,5-dienerhodium(I) chloride dimer and 61.5 mg (113.3 μmol) of 1-[1(R)-(di-tert-butylphosphino)ethyl]-2(S)- (diphenylphosphino)ferrocene were hydrogenated for 20 hours in 10 ml of methanol at 70° C. and 50 bar. A conversion of 67 percent was determined by NMR. The ee value was determined by hydrolyzing the ester (see Example 8).

Quellen und Nachweise

ORD-Eintrag
ord-e9db4f1f2d1d4136be49c4beea417404
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05945534

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