Sodium Carbonate → 4,4'-Bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyrimidine

HRID 1586936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1586936
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[N:14]=[C:13]([CH2:15]Cl)[CH:12]=[CH:11][N:10]=2)[N:4]=1.[NH:17]([CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].[C:34](=[O:37])([O-:36])[O-].[Na+].[Na+]>C(#N)C>[C:30]([O:29][C:27]([CH2:26][N:17]([CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[N:14]=[C:13]([CH2:15][N:17]([CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:23])[CH3:24])=[O:20])[CH2:26][C:34]([O:36][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:37])[CH:12]=[CH:11][N:10]=2)[N:4]=1)[CH2:18][C:19]([O:21][C:22]([CH3:24])([CH3:25])[CH3:23])=[O:20])=[O:28])([CH3:33])([CH3:32])[CH3:31]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 4393691DI-T-Butyl iminodiacetateHCID 197601294,4'-Bis(chloromethyl)-2,2'-bipyrimidine

Produkt 1

HCID 197601264,4'-Bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

4,4'-Bis(chloromethyl)-2,2'-bipyrimidine (18.0 mg, 0.0793 mmoles), di-t-butyl iminodiacetate (76.3 mg, 0.31 mmoles), sodium carbonate (210 mg) and acetonitrile (3 ml) were refluxed overnight. The mixture was filtered, the solvent was evaporated and the product was purified by flash chromatography (silica, 0-5% methanol/chloroform).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customthe solvent was evaporated
  3. customthe product was purified by flash chromatography (silica, 0-5% methanol/chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-3ae7fa321c324cd4a1d2146bfa9d575b
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05216134

Notizen zur Reaktion

Wird geladen…