1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → HCID 15288443, Verbindung
Reaktionsgleichung
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11](F)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1.[NH:20]1[CH2:24][CH2:23][CH:22]([C:25]2[C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:21]1>>[NH2:32][CH2:31][C:30]1[C:25]([CH:22]2[CH2:23][CH2:24][N:20]([C:11]3[CH:12]=[C:13]4[C:8]([C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5][N:4]4[CH:1]4[CH2:3][CH2:2]4)=[CH:9][C:10]=3[F:15])[CH2:21]2)=[N:26][CH:27]=[CH:28][CH:29]=1Komponenten
3
Versuchsvorschrift
Starting from 1 cyclopropyl 6,7 difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.80 g, 3.0 mmol) and 2-(3-pyrrolidinyl) 3-pyridine methanamine, a procedure analogous to that given in Example 1 provided the title compound (1.09 g, 86%) as an off white solid, mp 246°-248° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-0a6ba95a28a0497d856c6587b0e21057
- Quelldatensatz
- uspto-grants-1993_06