Acetyl chloride → HCID 19896706, Verbindung

HRID 1588333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588333
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][C:15]([OH:17])=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1.[C:20](Cl)(=O)C>CO>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][C:15]([O:17][CH3:20])=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 11065271HCID 11065271, Verbindung

Produkt 1

HCID 19896706HCID 19896706, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4-(3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-4-Oxo-3-methylbutyric acid (5 g) was suspended in methanol (50 ml) and acetyl chloride (0.5 ml) added. The mixture was heated on a steam bath until all of the solid dissolved. The solvent was evaporated at reduced pressure providing the ester as a white foam which was recrystallized from ethyl acetate-methanol to give the product as white crystals, yield 5 g, mp 95°-98° C.

Aufarbeitung

  1. temperatureThe mixture was heated on a steam bath until all of the solid
  2. dissolutiondissolved
  3. customThe solvent was evaporated at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0d9dfcf3a5f0431eba040eb878f71927
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05221742

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