Hydrazine → bemoradan

HRID 1588334Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588334
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=O)[CH:13]([CH3:18])[CH2:14][C:15](O)=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1.[NH2:20][NH2:21]>C(O)C>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]3[CH:13]([CH3:18])[CH2:14][C:15](=[O:16])[NH:20][N:21]=3)=[CH:11][C:5]=2[O:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 11065271HCID 11065271, Verbindung

Produkt 1

HCID 5362399bemoradanAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-(3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-4-oxo-3-methylbutyric acid (31 g, 0.12 moles) was dissolved in ethanol (300 ml) and anhydrous hydrazine (4.7 ml, 0.15 moles) was added. The mixture was heated at reflux overnight. White crystals formed after the mixture was cooled. The crystals were collected by filtration and washed well with ethanol. The solid was dried under vacuum giving 28.5 g (93%) of the titled compound, mp 299°-302° C.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux overnight
  3. customWhite crystals formed after the mixture
  4. temperaturewas cooled
  5. filtrationThe crystals were collected by filtration
  6. washwashed well with ethanol
  7. customThe solid was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9ab5686fe7e246cc8b97ed1e68459d7b
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05221742

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