p-Methylphenethylamine → N-cyano-N'-[2-(4-methylphenyl)ethyl]-2-pyridinecarboximidamide

HRID 1588512Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588512
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[C:13]1([CH3:22])[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH2:21])=[CH:15][CH:14]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:21][CH2:20][CH2:19][C:16]1[CH:17]=[CH:18][C:13]([CH3:22])=[CH:14][CH:15]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 76751p-MethylphenethylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

Produkt 1

HCID 19734557N-cyano-N'-[2-(4-methylphenyl)ethyl]-2-pyridinecarboximidamideAusbeute 93,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 2-(p-tolyl)ethylamine (0.47 g, 3.5 mmol) was added, and the resulting mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from methanoldiethyl ether to give the title compound (0.76 g, 2.9 mmol, yield: 93%) as colorless crystals.

Aufarbeitung

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from methanoldiethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-147b489c79434471beedc2ae3c01f153
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05223508

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