Isopropyl N-cyano-4-pyridinecarboximidate → N-cyano-N'-(3-benzyloxybenzyl)-4-pyridinecarboximidamide

HRID 1588551

Reaktionsgleichung

Reaktionsgleichung von HRID 1588551
[C:1]([N:3]=[C:4]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)OC(C)C)#[N:2].[CH2:15]([O:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26][NH2:27])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)=[N:27][CH2:26][C:25]1[CH:28]=[CH:29][CH:30]=[C:23]([O:22][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:24]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 10012715Isopropyl N-cyano-4-pyridinecarboximidateHCID 11009288(3-(Benzyloxy)phenyl)methanamine

Produkt 1

HCID 19734552N-cyano-N'-(3-benzyloxybenzyl)-4-pyridinecarboximidamideAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Isopropyl N-cyano-4-pyridinecarboximidate (0.30 g, 1.6 mmol) was dissolved in methanol (10 ml), and 3-benzyloxybenzylamine (0.42 g, 2.0 mmol) was added. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was then concentrated under reduced pressure. The residual concentrate was crystallized from methanol-diethyl ether to give the title compound (0.26 g, 0.8 mmol, yield: 48%) as colorless crystals.

Aufarbeitung

  1. concentrationthe reaction solution was then concentrated under reduced pressure
  2. concentrationThe residual concentrate
  3. customwas crystallized from methanol-diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-d9cc65899f784afa9ddb509c44657ef6
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05223508

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