Phenethylamine → N-cyano-N'-(2-phenylethyl)-3-furancarboximidamide

HRID 1588566Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588566
[C:1]([N:3]=[C:4]([C:7]1[CH:11]=[CH:10][O:9][CH:8]=1)OC)#[N:2].[C:12]1([CH2:18][CH2:19][NH2:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:11]=[CH:10][O:9][CH:8]=1)=[N:20][CH2:19][CH2:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 1001PhenethylamineHCID 19734520Methyl N-cyano-3-furancarboximidate

Produkt 1

HCID 19754249N-cyano-N'-(2-phenylethyl)-3-furancarboximidamideAusbeute 79,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl N-cyano-3-furancarboximidate (0.30 g, 2.0 mmol) was dissolved in methanol (10 ml), and 2-phenylethylamine (0.27 g, 2.2 mmol) was added. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.38 g, 1.59 mmol, yield: 79%) as colorless crystals.

Aufarbeitung

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f5f0c5589994447b8c68f71c47fffa48
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05223508

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