Dimethylformamide → 4-Formylbenzoic acid

HRID 1588919Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588919
S(Cl)(Cl)=[O:2].CN(C)[CH:7]=[O:8].[CH:10]1(NC2CCCC2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.C1[CH2:26][O:25]CC1>C1C=CC=CC=1>[C:26]([C:10]1[CH:11]=[CH:12][C:13]([CH:7]=[O:8])=[CH:14][CH:15]=1)([OH:25])=[O:2]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 24386Thionyl ChlorideHCID 219797n-Cyclopentylcyclohexanamine

Produkt 1

HCID 120884-Formylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

The acid chloride of 4-carboxybenzaldehyde (7.0 g, 46.5 mmol) was prepared in the same manner as in Example 29 using thionyl chloride (3.5 mL) and dimethylformamide (0.34 mL) in benzene (250 mL). The amide was prepared from the acid chloride in the same manner and using the same workup procedure as in Example 29 using N-cyclohexyl-N-cyclopentyl amine (15.6 g, 93.1 mmol) in THF (150 mL) at 0° C. The crude product was suitable for use without further purification.

Aufarbeitung

  1. customat 0° C
  2. customThe crude product was suitable for use without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a872729bfc2f4169ba1c28cdba5a239d
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05223539

Notizen zur Reaktion

Wird geladen…