Triethylamine → HCID 53933994, Verbindung

HRID 1588924Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588924
[C:1]([NH:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.C1(N(C2CCCCC2)[C:25](=[O:34])[C:26]2[CH:31]=[CH:30][C:29]([Br:32])=[C:28](C)[CH:27]=2)CCCC1>C1COCC1>[C:1]([N:5]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)[C:25](=[O:34])[C:26]1[CH:31]=[CH:30][C:29]([Br:32])=[CH:28][CH:27]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 103920N-tert-ButylcyclohexylamineHCID 19754882HCID 19754882, Verbindung

Produkt 1

HCID 53933994HCID 53933994, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a cold (0° C. to 5° C.) stirred solution of N-tertbutyl-N-cyclohexyl amine (3.73 g, 24 mmol) and triethylamine (2.5 g, 24 mmol) in dry THF (50 mL) is added dropwise a solution of acid chloride (5.0 g, 23 mmol) in THF (20 mL). The reaction is stirred at room temperature overnight and worked up in the same manner as for 4-bromo-3-methylbenzoic acid N-cyclopentyl-N-cyclohexyl amide. The crude product is purified by either recrystallization or by chromatography on silica gel using mixtures of ethyl acetate and hexane as eluents.

Aufarbeitung

  1. customThe crude product is purified by either recrystallization or by chromatography on silica gel using mixtures of ethyl acetate and hexane as eluents

Quellen und Nachweise

ORD-Eintrag
ord-215abfd26b2f4e69871890c1324462e1
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05223539

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