Hydrogen Peroxide → 4-(2-Hydroxyethoxy)phenol

HRID 1589120

Reaktionsgleichung

Reaktionsgleichung von HRID 1589120
CC([C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1)=C.OO.[OH:16]S(O)(=O)=O.[O-]S([O-])=O.[Na+].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[CH:12]=[CH:13][C:4]([OH:16])=[CH:5][CH:6]=1

Komponenten

6

Edukt 4

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 24437Sodium SulfiteHCID 137506132-(4-(1-Methylethenyl)phenoxy)ethanol

Produkt 1

HCID 98340144-(2-Hydroxyethoxy)phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a mixture of 2.50 g 2-(4-(1-methylethenyl)phenoxy)ethanol, 10 ml methanol, and 1.1 equivalents 50% aqueous H2O2 were added 0.1 equivalent 98% H2SO4. The reaction mixture warmed itself to reflux which subsided in a few minutes. After addition of 0.2 equivalent Na2SO3, methanol was removed under reduced pressure. The residue was taken up in ether, dried over Na2SO4 and NaHCO3, and filtered. Removal of solvent left 4-(2-(hydroxyethoxy)phenol in quantitative yield.

Aufarbeitung

  1. temperatureThe reaction mixture warmed itself
  2. temperatureto reflux which
  3. waitsubsided in a few minutes
  4. customwas removed under reduced pressure
  5. dry with materialdried over Na2SO4 and NaHCO3
  6. filtrationfiltered
  7. customRemoval of solvent
  8. waitleft 4-(2-(hydroxyethoxy)phenol in quantitative yield

Quellen und Nachweise

ORD-Eintrag
ord-cec16df0b1c044d2bfff9ae1791d2268
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04568497

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