Sodium Hydroxide → HCID 13588903, Verbindung

HRID 1589168Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1589168
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.Cl.Cl.[N:13]1([CH2:18][CH2:19][NH2:20])[CH:17]=[N:16][CH:15]=[N:14]1.[OH-].[Na+]>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:20][CH2:19][CH2:18][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[O:7])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 14798Sodium Hydroxide2×HCID 685154-Bromobenzoyl chlorideHCID 202483172-(1H-1,2,4-triazol-1-yl)ethan-1-amine dihydrochloride

Produkt 1

HCID 13588903HCID 13588903, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A mixture of about 2.2 g of 4-bromobenzoyl chloride, about 1.85 g of 1H-1,2,4-triazole-1-ethanamine dihydrochloride, about 30 ml of approximately 1N sodium hydroxide and about 75 ml of methylene chloride was stirred overnight, then about 5 ml of approximately 1N sodium hydroxide and about 75 ml of methylene chloride were added. The layers were separated and the organic layer was concentrated to remove the solvent. The crystalline residue was washed onto a filter with ether giving the desired product, mp 160°-162° C.

Aufarbeitung

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated
  3. customto remove the solvent
  4. washThe crystalline residue was washed onto
  5. filtrationa filter with ether giving the desired product, mp 160°-162° C.

Quellen und Nachweise

ORD-Eintrag
ord-86262e30502a4fde9c5178cfcb9d3f25
Quelldatensatz
uspto-grants-1986_02
Patentnummer
US04568685

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